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Т. 125, № 21Май 2015
GATA2 is critical for the maintenance of cellular identity in differentiated mast cells derived from mouse bone marrow

GATA2 plays a crucial role for the mast cell fate decision. We herein demonstrate that GATA2 is also required ...

Characterization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion by activation of BCR signaling

Multiple studies show that chronic lymphocytic leukemia (CLL) cells are heavily dependent on their microenvironment ...

Т. 125, № 20Май 2015
IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells

Carolina Schinke, Orsolya Giricz, Weijuan Li, Aditi Shastri, Shanisha Gordon, Laura Barreryo, Tushar Bhagat, ...

Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach

Oncogenic forms of NRAS are frequently associated with hematologic malignancies and other cancers, making ...

Т. 125, № 19Май 2015
Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia

Andrea Kühnl, Peter J. M. Valk, Mathijs A. Sanders, Adam Ivey, Robert K. Hills, Ken I. Mills, Rosemary ...

Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish

Isocitrate dehydrogenase 1 mutation (IDH1-R132H) was recently identified in acute myeloid leukemia with ...

Т. 125, № 18Апрель 2015
Generation of human memory stem T cells after haploidentical T-replete hematopoietic stem cell transplantation

Nicoletta Cieri, Giacomo Oliveira, Raffaella Greco, Mattia Forcato, Cristian Taccioli, Beatrice Cianciotti, ...

Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation

Alessandra Roberto, Luca Castagna, Veronica Zanon, Stefania Bramanti, Roberto Crocchiolo, James E. McLaren, ...

Т. 125, № 17Апрель 2015
BET bromodomain inhibition suppresses graft-versus-host disease after allogeneic bone marrow transplantation in mice

Acute graft-versus-host disease (GVHD) is the major obstacle of allogeneic bone marrow transplantation ...

Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein

Factor (F) XII, a key component of the contact system, triggers clotting via the intrinsic pathway, and ...

Т. 125, № 16Апрель 2015
Prognostic value of FDG-PET prior to autologous stem cell transplantation for relapsed and refractory diffuse large B-cell lymphoma

High-dose chemotherapy (HDT) plus autologous stem cell transplantation (ASCT) is the standard of care ...

Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow

The interaction of plasminogen with platelets and their localization during thrombus formation and fibrinolysis ...

Т. 125, № 15Апрель 2015
Lung parenchyma-derived IL-6 promotes IL-17A–dependent acute lung injury after allogeneic stem cell transplantation

Antiopi Varelias, Kate H. Gartlan, Ellen Kreijveld, Stuart D. Olver, Mary Lor, Rachel D. Kuns, Katie E.

Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assays

Protein C (PC) is a vitamin K–dependent plasma glycoprotein, which upon activation by thrombin in complex ...

Т. 125, № 14Апрель 2015
Crucial role for the VWF A1 domain in binding to type IV collagen

Veronica H. Flood, Abraham C. Schlauderaff, Sandra L. Haberichter, Tricia L. Slobodianuk, Paula M. Jacobi, ...

Inter-α inhibitor protein and its associated glycosaminoglycans protect against histone-induced injury

Extracellular histones are mediators of tissue injury and organ dysfunction; therefore they constitute ...

Т. 125, № 13Март 2015
Long-term outcome of Hurler syndrome patients after hematopoietic cell transplantation: an international multicenter study

Mieke Aldenhoven, Robert F. Wynn, Paul J. Orchard, Anne O’Meara, Paul Veys, Alain Fischer, Vassili Valayannopoulos, ...

Premature changes in trabecular and cortical microarchitecture result in decreased bone strength in hemophilia

Low bone density is a growing concern in aging men with hemophilia and may result in high-morbidity fragility ...

Т. 125, № 12Март 2015
Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor

The bidirectional signaling and hemostatic functions of platelet αIIbβ3 are regulated by kindlin-3 through ...

Adoptive T-cell therapy with hexon-specific Th1 cells as a treatment of refractory adenovirus infection after HSCT

Judith Feucht, Kathrin Opherk, Peter Lang, Simone Kayser, Lena Hartl, Wolfgang Bethge, Susanne Matthes-Martin, ...

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